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Richard and Smith [117] recently reviewed the literature on the chronic mental health effects of energy drinks

Rodent studies have shown ductal changes and low-grade inflammation, supporting a plausible biological link [32]

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Its entire evidence base is preclinical rodent work much of it from the lab that created the compound and there is a notable mismatch between how those studies dosed it (oral and peripheral) and how community sources describe taking it (subcutaneous and intranasal)

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