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Studies show that up to 25-40% of weight lost can be lean mass without countermeasures

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37 In addition, Zhang et al (2020) found that a single nucleotide polymorphism (SNP) in GLP-1R, rs2295006, was negatively associated with lumbar and total hip BMD in postmenopausal women, and similar observations have been made more recently by others

Physical activity boosts calorie burn and supports muscle health during weight loss