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These treatments are most effective with continued use

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GH-Axis : Due to age-related decline in pituitary function, older adults may require a longer cycle duration (16-24 weeks) and may need to use the standard or advanced doses of GHSs to achieve a therapeutic effect

tesamorelin ipamorelin sermorelin vs vs Tesamorelin: Key Differences (2026) Tesamorelin vs Ipamorelin: Key Differences,

References StatPearls (NCBI Bookshelf) Farzam K, Patel P

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