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According to literature, Asn240 is involved in the stabilization of a conserved water molecule, which is required for the deprotonation of monophenolic substrates

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and studies investigating the role of glutamatergic agonists to combat NMDAR hypofunction and reduce symptoms [7]

By correctly phenotyping irAEs and understanding the varied presentations and natural history, we can begin to develop a framework to distinguish between AEs associated with conventional chemotherapy or targeted therapy and immunotherapy