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Even the combination regimen of anti-CTLA4 (ipilimumab) and anti-PD1 (nivolumab) agents merely witness a slight increased ORR to 37% with PFS at 5.9 month (136, 175)

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Tirzepatide (Mounjaro) : As monotherapy for eligible patients, offering superior weight loss compared to earlier GLP-1 agonists in head-to-head trials

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