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Moreover, recent study found that hypoxia-inducible factor (HIF)1 and HIF-2 in GBM cells jointly mediate upregulation of the mRNA and protein expression levels of the BCAAs transporter LAT 1 and the BCAAs metabolizing enzyme BCAT1, and ultimately promote the growth of cells under hypoxia conditions

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Yoo S-E, Chen L, Na R, Liu Y, Rios C, Van Remmen H et al (2012) Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain