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Combination therapy changes risk profile

13 Less common but important side effects include: Gallstones (rare) Kidney problems, especially in older adults who already have kidney disease Significant weight loss, which could be concerning for frail elderly people Special considerations for older adults: Stomach problems can lead to dehydration, which can be more serious in older adults

All three medications reduced alcohols interoceptive effects, meaning they diminished the subjective experience of being intoxicated