The skin relies on three load-bearing pillars: subcutaneous fat pads, a collagen-elastin matrix in the dermis, and the underlying musculature
(Safety and efficacy of secukinumab in psoriasis patients infected with hepatitis B virus: a retrospective study.) Radi G, Campanati A, Diotallevi F, Rizzetto G, Martina E, Bobyr I, Giannoni M, Offidani A (2021) Long-term efficacy and safety of apremilast in the treatment of plaques psoriasis: a real-world, single-center experience
Worsening depression or suicidal thoughts
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At the end of the trial, seven of the participants had significantly increased bowel movement frequency, reduced constipation symptoms, and improved quality of life, with no adverse events (Queralto 2013)