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People who are recovering from tendon, ligament, or muscle injuries, with persistent gut disorders (IBD, ulcers, leaky gut), inflammation or tissue damage from NSAIDs, wanting speedier surgery or injury recovery, managing brain-gut dysfunction or systemic inflammation

However, urine output is not a very reliable index in patients who are taking medication or are perioperative, and other commonly used surrogate indices, such as the serum creatinine concentration, creatinine clearance, or GFR, can only show that AKI and functional impairment is already present, rather than being predictors of their development at an early stage (113)