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Many factors can contribute to weight challenges during midlife including hormonal shifts that can affect appetite and energy, which is why the standard eat less, move more weight-loss advice often doesnt cut it during this chapter

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It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants, and people with severe obesity on the highest dose lost an average of 30% of their body weight over two years, said Ania Jastreboff, the lead investigator of the study, in a press release