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If hypersensitivity reactions occur, discontinue use of WEGOVY, treat promptly per standard of care, and monitor until signs and symptoms resolve

To further evaluate the invasion and the distribution area of RBITC-GLP-1RAs@NPs-WYRGRL in articular cartilage, RBITC-GLP-1RAs@NPs or RBITC-GLP-1RAs@NPs-WYRGRL was injected into the joint cavity, then the fluorescence intensity of articular cartilage tissue sections was observed and calculated on the first and third days (Fig