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Participants receiving the highest maintenance dose (12 mg once weekly) achieved a mean body weight reduction of approximately 24% from baseline in those without type 2 diabetes a notably larger effect than that observed with currently approved agents in comparable timeframes

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Additionally, within this observational timeframe, individuals undergoing metformin intervention manifested notable reductions in concentrations of advanced oxidation protein products (AOPP) and advanced glycation end products (AGE) in comparison to the control group (Mirmiranpour et al., 2013)

doi:10.1038/nchembio.499 53