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Hence, understanding dopamine receptor signaling and avoiding the activation of downstream events that produce side effects is an approach for improving PD therapies

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Microglial activation plays a critical role in the pathogenesis of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyidine- (MPTP-) induced Parkinson's disease model and human Parkinson's disease [27]

When adverse effects occur, they may include mild skin reactions, gastrointestinal disturbance, or headache, typically following high-dose intramuscular injections rather than oral supplementation

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