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Clinical trials document typical outcomes of 15-20% body weight loss over 12-18 months, representing substantial, well-documented metabolic effects

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Also, pyruvate dehydrogenase kinase isoenzyme-4 encodes pyruvate dehydrogenase complex (PDK)

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One 2020 study found that when a GLP-1 receptor agonist was injected into specific areas of the brain in male mice, it reduced their sexual behaviors

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