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Johansen, T.T
In the phase 2 trial, the most reported side effects were: Nausea (affecting around 40-50% of participants at higher doses) Vomiting Diarrhoea Constipation Decreased appetite (which is also the intended effect) Most of these were mild to moderate and occurred during the dose escalation phase
Although some improvements in pigmentation were observed in subgroups, results were mixed and highlighted the need for consistent use and further research Health+15CDEK Pharmacy+15ClinicalTrials.gov+15
Pathological alterations in gut microbiota induce the increased production of toxic metabolites and reduced production of beneficial compounds like short-chain fatty acids