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We received a few comments on the proposed changes to the quality EUC policy that we consider to be out of scope and will not be addressing these comments in this final rule

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It is postulated that women have more arterial stiffening with aging that sacubitril-valsartan may more effectively counter or that natriuretic peptides, which are generally lower in women, are more impacted by the medical therapy and may therefore lead to a stronger effect

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Researchers are still untangling the exact contributions of each mechanism, but the current evidence points to three major factors working together