This hypothesis was confirmed by several studies that had reported an important correlation between GSH levels and its positive effect on the active vitamin D ratio in the body where they showed that GSH deficiency is associated with increased oxidative stress where they epigenetically alter vitamin D regulatory genes and, as a result, the suppressed gene expression decreases vitamin D biosynthesis, ultimately leading to a secondary deficiency of vitamin D3
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The related primer sequences are shown in Supplementary Table S2
[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Hill K.E., McCollum G.W., Boeglin M.E., Burk R.F
In addition, the interaction of carotenoids with other co-antioxidants, primarily vitamins E and C significantly enhances their effectivity as antioxidants