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Crucially, pair-feeding and semaglutide produced virtually identical effects on muscle, showing that muscle loss was driven by reduced calorie intake and not by anything specific to GLP-1 signaling

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doi: 10.1016/j.cub.2020.09.068 190 ConradMPrattDA

It was actually FDA-approved twice : once in 1990 as a diagnostic agent for GH deficiency, and again in 1997 as a treatment for childhood GH deficiency

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