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3, Oncogenic PI3K/AKT signaling stabilizes and activates nuclear factor erythroid 2related factor 2 (NRF2), a key regulator of antioxidant genes, driving upregulation of GSH biosynthetic enzymes

Specifically, AIF and caspase-3 play critical roles in caspase-independent and caspase-dependent apoptosis, respectively

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Zhuang W, et al

Abstract Although the multifaceted mechanisms underlying alcohol use disorder (AUD) have been partially defined, the neurobiological complexity of this disorder is yet to be unraveled