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de , Growth of WT, gsh2 , and gsh2::GSH2 cells in 5 ml liquid cultures of l-DOPA medium (with or without GSH supplementation in e )

Legitimate Research Directions: Some peptides DO have potential and are being properly studied: Thymosin Alpha-1: Immune support (approved in 35+ countries, trials in US) BPC-157: IF proper human trials ever happen LL-37: Antimicrobial applications Others: Many peptides have theoretical promise But ONLY if studied properly: Randomized controlled trials Safety studies FDA approval process Medical supervision The Problem: Most "wellness peptides" will NEVER go through this process because: They can't be patented (no profit incentive) Companies would rather sell in gray market Proper trials cost $100M+ If trials show they DON'T work, the market disappears So we're stuck in limbo: promising animal data, zero human data, aggressive marketing

Risk of bias assessment We used the Cochrane Risk of Bias Assessment Tool (22), and all the included trials were of good quality

Respective precursor plasmids and primers are reported in Supplementary Tables 4 and 5

Daily injection checklist: Verify patient ID and current dose, match vial lot