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To understand the mechanism by which rhGH could stimulate the early onset of puberty in males, changes in hypothalamic kisspeptin, GnRH and IGF1 levels, pituitary and circulating LH, spermatogenesis, testicular steroidogenesis, and IGF1 in the circulation, liver, and testes were examined in immature rats following prepubertal rhGH treatment

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Moreover, polyphenols often act on multiple pathways simultaneously, raising concerns of off-target effects that may not be fully elucidated in preclinical models

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