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Mechanical loading reveals an intrinsic cardiomyocyte stiffness contribution to diastolic dysfunction in murine cardiometabolic disease

Design and evaluation of an external control arm using prior clinical trials and real-world data

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The subjects were equally block-randomized into three groups: GSSG (250 mg/d), GSH (250 mg/d), or placebo

Central nervous system tissue analyses further reveal lesion-associated methylation changes affecting myelin biology and glial programs, associating epigenetic remodeling to demyelination and repair potential (137)