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Acetyl-L-Carnitine in Neuropathic Pain Experimental Data Santina Chiechio Agata Copani Robert W Gereau Ferdinando Nicoletti Acetyl-L-carnitine (ALC) has gained clinical interest for its analgesic effect in different forms of neuropathies associated with chronic pain, such as diabetic and HIV-related peripheral neuropathies

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Entry of fatty acids into the mitochondria relies on carnitine palmitoyltransferase 1 (CPT1) situated in the outer mitochondrial membrane [80], but as the mitochondria lack the ability to oxidize very long chain fatty acids [79], these are preferably metabolized via peroxisomal -oxidation

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