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1 Introduction Demyelinating diseases are mainly characterized by damage to the myelin sheath wrapping the central nervous system (CNS) axons or to oligodendrocytes themselves ( The main representative group of these primary demyelinating spectrum disorders are multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), acute disseminated encephalomyelitis (ADEM) and myelin oligodendrocyte glycoprotein associated diseases (MOGAD)

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5.4 Air pollution Air pollution is recognized as one of the leading global threats to human health, playing a crucial role in the development of both hypertension and lung cancer