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doi: 10.1038/s41418-023-01125-0

Missteps in timing, dosage, or stacking can lead to diminished results or significant side effects

Glutathione Chen J., et al

Without supplementation, deficiency is nearly universal within 23 years People taking metformin long-term metformin use reduces B12 absorption by 1030% through calcium-dependent ileal uptake disruption [4] People taking PPIs or H2 blockers acid suppression impairs B12 release from food proteins