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In an animal study, inhibition of the NF-B pathway led to a significant reduction in the expression of serum proinflammatory cytokines, including IL-6, IL-1 and TNF-, as well as an increase in the expression of the tight junction proteins occludin and ZO-1, thereby improving the function and structure of the intestinal mucosa

Histopathological assessment further revealed pronounced degenerative changes in the testes, epididymis, seminal vesicles, and prostate

In the final section, we will discuss epigenomes causing glial heterogeneity and possible association with glial senescence

An earlier study published in Nature Medicine in January 2025 mapped the benefits and risks of GLP-1 drugs across 175 health outcomes in more than 2 million veterans, finding reduced risks for dementia, Alzheimers disease, psychotic disorders and seizures alongside known risks for pancreatitis and kidney problems

10.3389/fphys.2020.00805 27 ChokshiA.DrosatosK.CheemaF