Fungal-targeted nanoconstructs (FTNx), using antisense oligonucleotides against FKS1 and CHS3 , can inhibit fungal cell wall synthesis genes, reduce fungal burden and improve survival in murine candidiasis models, exhibit broad-spectrum antifungal activity, including against clinical isolates of Candida auris ( Li et al., 2025a)
Folinic acid promotes methylation reactions crucial for gene regulation and detoxification
While this strict timing can be challenging for some, it eliminates the need for injections altogether
Availability and Prescribing Status in the UK Neither compound is routinely available in the UK: tesamorelin requires named-patient importation as an unlicensed medicine, and retatrutide is only accessible through regulated clinical trials
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