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Kidney disease, whether chronic or acute injury, also represents an absolute contraindication

57 However, the clinical applications of EA have been limited, due to its diuretic properties and lack of enzyme specificity, with long-term intake possibly risking water and salt imbalance

Dipeptidyl-peptidase IV from bench to bedside: An update on structural properties, functions, and clinical aspects of the enzyme DPP IV

Separate lines of study also propose that GHK-Cu may enhance collagen synthesis, including types I and IV, particularly when combined with hyaluronic acid under controlled test conditions