Similar content being viewed by others Introduction Glutathione is a biologically active tripeptide composed of glutamic acid, cysteine, and glycine (Kobayashi et al., 2022)
Reduced glutathione (GSH) acts as peroxide scavenger and its oxidised form (GSSG) can be further reduced by glutathione reductase (GR) using NADPH as substrate [16]
It has fewer ingredients than some similar supplements, but its ingredients have a fair bit of positive support behind them
Sources of depletion can include: Mitochondrial energy production (a normal and essential process, but creates harmful byproducts like ROS) Chronic infections, gut dysbiosis (including SIBO and Candida ), and ongoing inflammation Air pollution, heavy metals, and environmental toxins 17 Ultra-processed foods, sugar-sweetened beverages, and foods high in advanced glycation end products (heavily browned foods) 18 Pesticides and herbicides 19 Alcohol and smoking Psychological stress Even vigorous exercise (a healthy stressor that still creates oxidative byproducts) 20 Understanding this helps explain why simply eating well sometimes isnt enough, and why targeted nutritional strategies make a meaningful difference
Takemura K, Kawachi H, Eishi Y, Kitagaki K, Negi M, Kobayashi M, et al
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