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GHK-Cu (10 M, 24h in primary hepatocytes) induces MT-1A mRNA +2.4 0.4-fold and MT-2A +2.1 0.3-fold (RT-qPCR

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Each route has revealed dose-dependent effects on tissue repair outcomes, pointing toward consistent underlying mechanisms rather than route-specific artifacts

(11) This has led to the hypothesis that exogenous FOXO protein, such as FOXO4-DRI peptide, may help regulate optimal levels of FOXO proteins, thereby preventing or alleviating the progression of any NDDs associated with this mechanism