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However, growing evidence indicates that alternative metabolic routes such as malic enzyme 1 (ME1), isocitrate dehydrogenases (IDH1 and IDH2), and the folate cycle also significantly contribute to NADPH production, particularly under stress conditions or during metabolic reprogramming [43]

5 BatlaA.SimeoniS.UchiyamaT.deMinL.BaldwinJ.MelbourneC.et al (2021)

The human brain due to the high oxygen consumption is extremely susceptible to the generation of reactive oxygen species

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