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The primary and most important mechanism of how Botox works for chronic migraine is by disrupting the electrical communication signals of pain between nerves involved in migraine pathophysiology and ultimately stopping these signals from reaching the pain circuitry of the brain
Both can be injected subcutaneously at the same anatomical site (abdomen, thigh) but as distinct injections administered sequentially
J Frailty Aging
There is no controlled human trial data on these combinations
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