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Activation of NOX enzymes in Kupffer and hepatic stellate cells induces ROS generation, thereby promoting liver fibrosis and hepatocarcinogenesis 93,94,95,96

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Caffeine can stimulate the production of free radicals in the body

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In this paper, we present a new integrated model for hepatic glutathione metabolism including one-carbon metabolism and use it to investigate how the activation of certain enzymes by estradiol in one-carbon metabolism and glutathione metabolism leads to dramatic changes in reaction velocities and metabolite concentrations, including GSH and the GSH synthesis rate