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However, even with peptides, the body must be able to recognize and utilize these building blocks
3319-A HOST PRECONDITIONING AND TRANSIENT MITOGEN EXPRESSION VIA mRNA-LNP LEAD TO ROBUST PRIMARY HUMAN HEPATOCYTE ENGRAFTMENT AND TRANSIENT iPSC-DERIVED HEPATOCYTE SURVIVAL IN A MURINE MODEL OF AATD LIVER DISEASE Anna R Smith 1 , Fatima Rizvi 1 , Elissa Everton 1 , Anisah Adeagbo 1 , Hua Liu 1 , Ying Tam 2 , Norbert Pardi 3 , Drew Weissman 3 and Valerie Gouon-Evans 1 , (1)Boston University School of Medicine, (2)Acuitas Therapeutics, (3)University of Pennsylvania Perelman School of Medicine Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic disease caused by a single base pair mutation of the SERPINA1 gene and increases risk of liver and lung disease
doi: 10.1016/j.peptides.2013.07.002 Low, Dolyce H
Previous studies suggest that GCL is localized to the chloroplasts and GS is localized both to chloroplasts and cytosol in plant cells (Hell and Bergmann, Arabidopsis suggests that GCL and GS are each encoded by a single gene with alternate transcription start sites leading to either plastid-targeted or cytosolic protein (Wachter et al., 2005)
