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10.3390/cells10102586 100 SkrticM.SriskanthadevanS.JhasB.GebbiaM.WangX.WangZ.et al (2011)

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However, safety requires acknowledging that both compounds affect metabolic rate and energy utilization, meaning combined use demands careful monitoring

GLP-1 agonists such as Ozempic should generally be avoided in individuals with: A personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN2) A prior history of pancreatitis Progressive diabetic retinopathy, particularly in those with long-standing or poorly controlled diabetes Congestive heart failure, where fluid balance, heart rate, and medication interactions require close monitoring (35) A thorough medical history and medication review are essential before initiating therapy to determine whether GLP-1 agonists are appropriate or contraindicated