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This results from the impairment of bloodbrain barrier tight junction expression, endothelial cells, and alterations to transport pathways caused by proinflammatory cytokines, LPS, toxic activated T cells (e.g., CD40L + ), ROS, O&NS, neurovascular dysfunctions, and increased free cholesterol levels [1, 205,206,207,208]

[1] This is fundamentally different from the standard medical guidance, which is designed to ramp you up to a high dose to maximize weight-loss outcomes

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For example, there is promising research emerging indicating that specifically formulated folate supplements can reduce the unintended reading of certain genes (a downstream effect discussed above) and therefore can decrease the severity and risk of certain psychiatric disorders in people with the MTHFR mutation