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For some, the peak is too high, leading to intense nausea, while the trough is too low, leading to food noise or hunger returning a day or two before the next shot

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After a 4-week screening period, participants were randomly assigned, 1:1:1:1:1, to once-weekly 2.5 mg, 5 mg, 10 mg or 15 mg VK2735 or placebo for 13 weeks

This is caused by shifts in hormone levels as your body adapts to lower fat mass, not by damage to reproductive organs

A majority were assigned to grade I obesity (59.15%), 23.54% were classified as grade II, and 12.03% as grade III obesity