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5 TMAO-mediated immunometabolism in IBD Emerging evidence highlights TMAOs dual role as both a biomarker of microbial-host metabolic crosstalk and a direct instigator of immune-inflammatory cascades, bridging gut dysbiosis to intestinal mucosal damage (86)

Thus, the selected starting dose and titration algorithm in the IcoSema phase 3 programme account for the higher maximum concentration of semaglutide in IcoSema and are expected to provide an acceptable gastrointestinal adverse event profile

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