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A 2025 systematic review and meta-analysis of 18 randomized trials involving 3,771 participants found that after GLP-1 receptor agonist discontinuation in obesity, average rebound included +5.63 kg body weight, +0.25% HbA1c, plus worsening in waist circumference, BMI, systolic blood pressure, and fasting plasma glucose

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Eligibility for GLP-1 treatment plans in the UK is determined by NICE guidance, which provides specific criteria for both diabetes management and weight management indications

This is also mirrored in growth hormone production