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Within this framework, the gut-brain axis (GBA) is a key upstream regulator of peripheral KP metabolism and depressive symptom expression [174]

However, PRP may not be the best route for everyone

It was hypothesized that a 15-amino acid motif located upstream (RKQRRERTTFTRAQL, RK-peptide) of the Otx2 homeodomain is the CS-binding sequence

Oxidized PAC-quinone imine metabolites have also been shown to form GSH-conjugates which inhibit glutathione reductase (GR): the decreased activity of GR hampers the detoxification and antioxidant capacity of the GSH-GSSG cycle, further aggravating the pro-oxidative status in the cell (Ndlov et al., 2014)

On the contrary, the inhibition of H3Q5dop in mPFC has no effect on behavior, indicating that its effect is region-specific