At Week 68, the body weight was missing for 3%, 3%, and 1% of patients randomized to WEGOVY 1.7 mg injection, WEGOVY 2.4 mg injection, and placebo, respectively
The complexity of peptide drug development, specialized production requirements, and the need for long-term clinical data further limit new entrants
Early data suggests that while retatrutide produces more dramatic weight loss, the gastrointestinal side effect patterns may differ from those seen with semaglutide alone
Avoid high-fat meals, cruciferous vegetables (broccoli, cauliflower, cabbage), legumes (beans, lentils), artificial sweeteners (sorbitol, xylitol), and carbonated drinks, as these are harder to digest or produce excess gas when gastric emptying is slowed
Retatrutide has created major attention because many people call it the next big thing after Ozempic, Wegovy, Mounjaro, and Zepbound