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3.4 Early PsA and future research directions Despite the promising metabolic and immunomodulatory effects observed in PsO, the role of GLP-1RAs in PsA, particularly in its early stages, remains largely unexplored

A direct comparison of P5 with the reference peptide Ex4 revealed that G-protein signalling downstream of GLP-1R activation in the absence of -arrestin signalling is sufficient to correct hyperglycaemia, improve insulin sensitivity, preserve pancreatic islet integrity and improve liver steatosis

Catalano PM, Mele L, Landon MB, Ramin SM, Reddy UM, Casey B, et al

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