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Additionally, significant changes were noted in the composition of the bone matrix of these animals, with decreased enzymatic cross-linking of the collagenous matrix, which clearly worsened the compromised biomechanical strength and contributed to the observed bone fragility [44]

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mean BMI 37.00) completed the low-calorie diet and were randomized into four groups: exercise (48 participants), liraglutide (49 participants), combination (49 participants), and placebo (49 participants)

Both drugs contain the same active ingredient and are classified as glucagon-like peptide-1 (GLP-1) receptor agonists