The mazdutide comparison shows another dual-agonist approaching the market
With this partial Modigy [28] workflow, a total of 9 interfacial salt bridges (Table 6) were identified at the binding interface of GLP-1R ECD and semaglutide analogue A747 (supplementary file A747.pdb ), in comparison with 2 interfacial salt bridges (Table 1) for PDB entry 4ZGM [24, 35]), and in comparison with 7 interfacial salt bridges (Table 4) for supplementary file 4452.pdb
Studies suggest roles in reproductive signaling, but evidence is still limited
Acknowledgements We thank our collaborators in related studies: at Uppsala University, in particular, Per Lundkvist
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