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Although there have been no specific trials to show cardiorenal benefit for GLP-1RA or SGLT2i when used as first-line therapy or as monotherapy or in newly diagnosed T2D, the benefit seen in the CV outcome trials has not been found to vary with the duration of diabetes, suggesting that similar benefits might be seen early in the course of disease.4 The benefits are also not dependent on the presence of metformin
The Endocrine Society's 2024 guidelines state that dose optimization should be guided by HbA1c response and tolerability rather than automatic escalation to the maximum dose 8
Children (2017)
Celiac testing should include tissue transglutaminase IgA (tTG-IgA) with total IgA levels
Additionally, cytosolic LPS is directly sensed by inflammatory caspases (e.g., Caspase-4), triggering non-canonical inflammasome responses and pyroptosis, which further amplifies systemic inflammation 144
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