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O -glycosides (e.g., isoquercitrin) are typically hydrolyzed in the upper gastrointestinal tract to release aglycones like quercetin, while C -glycosides (e.g., orientin, vitexin), due to their structural stability, are only metabolized into absorbable forms in the colon by gut microbiota (Xie et al., 2022)

The estrogen-ER pathway is central to breast carcinogenesis, circulating oestrogens e.g

PMID 23539619

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Researchers examine dose-response relationships and time-course effects to characterize how the peptide interacts with the stress hormone cascade under controlled laboratory conditions