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While causation cannot yet be established, vitamin D status may serve as a biomarker of metabolic response to semaglutide

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Certain patient populations should have detailed discussions about potential heart rate effects before initiating tirzepatide therapy

Previous results indicate that TNC is downregulated by GLP-1RA treatment and correlates with incident CVD 43 , suggesting that TNC may act as a mediator, with downregulation contributing to the cardiovascular-protective effects of GLP-1RAs