What is already known on this topic The development of highly effective weight management medications (WMMs) has transformed the treatment of obesity Real world observations estimate that around 50% of people with obesity discontinue WMMs within 12 months A previous systematic review quantified and compared the rate of weight regain with behavioural weight management programmes (BWMPs) What this study adds People on average regain weight at a rate of 0.4 kg/month after cessation of WMMs, leading to a projected return to baseline weight after 1.7 years Although weight loss resulted in improvements in HbA 1c , fasting glucose, total cholesterol, triglycerides, systolic and diastolic blood pressure, all markers returned to baseline within 1.4 years of treatment cessation The rate of weight regain after the cessation of WMMs was faster than after the cessation of BWMPs, independent of the amount of weight lost during treatment Ethics statements Ethical approval Not required
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Chronic low-grade inflammation is a genuine pathological feature of PCOS, and emerging research on the gut-ovary-brain axis suggests that gut microbiome dysbiosis may contribute to hypothalamic GnRH dysregulation
Semaglutide might be the solution youve been looking for
Un artculo publicado en la Revista Espaola Nutricin Hospitalaria, ha sugerido que la carnitina puede mejorar el metabolismo de los cidos grasos y reducir la acumulacin de lpidos en tejidos como el hgado y los msculos, lo que podra contribuir a una mejor regulacin de la glucosa
