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Authors contributions: Vignesh NR and Sakthi Megalai: Contributed to the definition of intellectual content and literature search, Balakumaran C and Sowbaghya PT: Contributed to data and statistical analysis as well as manuscript preparation

Studies in mammalian cell culture reveal that supplementation with IGF-1 LR3 at concentrations significantly lower than standard insulin or native IGF-1 results in enhanced cell productivity and proliferation rates

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