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According to meta-analysis data, hypothyroidism occurs in about 3.8% of patients treated with anti-CTLA-4, 3.9% with anti-PD-L1, 7.0% with anti-PD-1, and 13.2% with combination therapy

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reported a competitive small molecule antagonist V-9302, which selectively targeted the ASCT2 transporter for glutamine influx inhibition (Schulte et al., 2018)

Wilson Disease